Clemizole
产品介绍
Clemizole,又称克立咪唑、吡咯咪唑或克敏唑,是组胺受体(H1 receptor)拮抗剂,通过抑制NS4B的RNA结合表现出抗丙型肝炎(HCV)病毒的活性。
产品性质
产品特色
参考文献
[1] Einav S, et al. Discovery of a hepatitis C target and its pharmacological inhibitors by microfluidic affinity analysis. Nat Biotechnol. 2008 Sep;26(9):1019-27.
[2] Nishimura T, et al. Using chimeric mice with humanized livers to predict human drug metabolism and a drug-drug interaction. J Pharmacol Exp Ther. 2013 Feb;344(2):388-96.
[3] Richter JM, et al. Clemizole hydrochloride is a novel and potent inhibitor of transient receptor potential channel TRPC5. Mol Pharmacol. 2014 Nov;86(5):514-21.
存储条件
冰袋运输。粉末直接保存于-25~-15℃,有效期3年。建议分装后-25~-15℃干燥保存,避免反复冻融。
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