Flavopiridol Hydrochloride (Alvocidib Hydrochloride, L86-8275 Hydrochloride, HMR-1275 Hydrochloride)，又称夫拉平度盐酸盐，是ATP竞争性的CDK广谱抑制剂，作用于CDK1/2/4/6的选择性比作用于CDK7高，可抑制细胞增殖，具有抗癌活性。Flavopiridol Hydrochloride也可抑制EGFR和PKA。

参考文献

1. Mahoney E, et al. ER stress and autophagy: new discoveries in the mechanism of action and drug resistance of the cyclin-dependent kinase inhibitor flavopiridol.Blood. 2012 Aug 9;120(6):1262-1273.
2. Senderowicz AM. The cell cycle as a target for cancer therapy: basic and clinical findings with the small molecule inhibitors flavopiridol and UCN-01. Oncologist. 2002;7 Suppl 3:12-9.
3. Arguello, F, et al., Flavopiridol induces apoptosis of normal lymphoid cells, causes immunosuppression, and has potent antitumor activity In vivo against human leukemia and lymphoma xenografts. Blood, 1998. 91(7): p. 2482-90.

冰袋运输。粉末直接保存于-20℃，有效期3年。建议分装后-20℃干燥保存，避免反复冻融。