Fludarabine (Fludarabinum, NSC118218, NSC 118218, FaraA)，又称氟达拉滨，是一种嘌呤类似物，可以抑制DNA合成。Fludarabine是STAT1抑制剂，特异性降低STAT1蛋白和mRNA水平，但不影响其他STATs，在淋巴增生性恶性肿瘤中有抗肿瘤活性，主要用于治疗B细胞慢性淋巴细胞性白血病和非霍奇金淋巴瘤。

参考文献

[1].Meng H, et al. Antitumor activity of fludarabine against human multiple myeloma in vitro and in vivo. Eur J Haematol. 2007;79(6):486-493.

[2].Fernández-Calotti P, et al. Fludarabine induces pro-inflammatory activation of human monocytic cells through a MAPK/ERK pathway. Int Immunopharmacol. 2006;6(5):715-23.

[3].Torella D, et al. Fludarabine prevents smooth muscle proliferation in vitro and neointimal hyperplasia in vivo through specific inhibition of STAT-1 activation. Am J Physiol Heart Circ Physiol. 2007;292(6):H2935-43.

[4].Zhou C, et al. STAT3 upregulation in pituitary somatotroph adenomas induces growth hormone hypersecretion. J Clin Invest. 2015;125(4):1692-702.

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