Obatoclax Mesylate (GX15-070 Mesylate)，又称奥巴克拉甲磺酸盐，是BH3模拟物，是Bcl-2拮抗剂，K_i值为0.22 μM，通过结合Bcl-2的BH3结合位点抑制Bcl-2活性，诱导BAX或BAK依赖性的细胞凋亡，具有抗癌活性。

参考文献

1.Nguyen M, et al. Small molecule obatoclax (GX15-070) antagonizes MCL-1 and overcomes MCL-1-mediated resistance to apoptosis. Proc Natl Acad Sci U S A. 2007 Dec 4;104(49):19512-7.

2.Or CR, et al. Obatoclax, a Pan-BCL-2 Inhibitor, Targets Cyclin D1 for Degradation to Induce Antiproliferation in Human Colorectal Carcinoma Cells. Int J Mol Sci. 2016 Dec 27;18(1).

3.Marina Konopleva, et al. Mechanisms of Antileukemic Activity of the Novel Bcl-2 Homology Domain-3 Mimetic GX15-070 (Obatoclax). Cancer Res May 1, 2008 68; 3413.

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