Vortioxetine (Lu AA 21004)，又称沃替西汀，是小分子哌嗪类硫化物，抗抑郁药，用于治疗重度抑郁症，主要通过增加中枢神经系统的5-HT浓度发挥抗抑郁作用，是5-HT再摄取抑制剂，抑制5-羟色胺转运体(SERT)。此外，Vortioxetine也是5-HT_1A、5-HT_1D、5-HT_3A和5-HT₇受体的拮抗剂。

参考文献

1.Bang-Andersen B, et al. Discovery of 1-[2-(2,4-dimethylphenylsulfanyl)phenyl]piperazine (Lu AA21004): a novel multimodal compound for the treatment of major depressive disorder. J Med Chem. 2011 May 12;54(9):3206-21.

2.Guilloux JP, et al. Antidepressant and anxiolytic potential of the multimodal antidepressant vortioxetine (Lu AA21004) assessed by behavioural and neurogenesis outcomes in mice. Neuropharmacology. 2013 Oct;73:147-59.

3.Theunissen EL, et al. A randomized trial on the acute and steady-state effects of a new antidepressant, vortioxetine (Lu AA21004), on actual driving and cognition. Clin Pharmacol Ther. 2013 Jun;93(6):493-501.

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