2-D08 (2D-08, 2',3',4'-trihydroxy flavone)是有细胞透性的蛋白SUMO化抑制剂。2-D08 通过阻止 SUMO从UBC9-SUMO硫酯转移到底物来抑制SUMO化修饰。SUMO化修饰是类似泛素化修饰的过程，与目标蛋白质上特定的赖氨酸支链形成共价键修饰目标蛋白质，在癌症中起着关键作用。

参考文献

1.Kim YS, et al. Synthesis of 2',3',4'-trihydroxyflavone (2-D08), an inhibitor of protein sumoylation. Bioorg Med Chem Lett. 2014 Feb 15;24(4):1094-7.

2.Fujino N, et al. Phenotypic screening identifies Axl kinase as a negative regulator of an alveolar epithelial cell phenotype. Lab Invest. 2017 Sep;97(9):1047-1062.

3.Ghosh H, et al. Several posttranslational modifications act in concert to regulate gephyrin scaffolding and GABAergic transmission. Nat Commun. 2016 Nov 7;7:13365.

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