SIS3 HCl ((E)-SIS3, SIS-3 HCl)，又称SIS 3盐酸盐，是一种新型的、具有细胞通透性的Smad3选择性抑制剂，抑制TGF-β1/ALK5诱导的的Smad3磷酸化，IC₅₀为3 μM。SIS3对Smad2、ERK、MAPK/p38或PI3-kinase信号无影响。

参考文献

[1].Jinnin M et al. Characterization of SIS3, a novel specific inhibitor of Smad3, and its effect on transforming growth factor-beta1-induced extracellular matrix expression. Mol Pharmacol. 2006 Feb;69(2):597-607.

[2].Li J, et al.Blockade of endothelial-mesenchymal transition by a Smad3 inhibitor delays the early development of streptozotocin-induced diabetic nephropathy. Diabetes. 2010 Oct;59(10):2612-24.

冰袋运输。粉末直接保存于-25~-15℃，有效期3年。建议避光干燥保存，避免反复冻融。