IWP-O1 (IWPO1, IWP O1)是有效Porcn的抑制剂，Porcn是一种酰基(palmitoyl)转移酶，在L-Wnt-STF细胞中测定其EC₅₀为80 pM，也可抑制Wnt蛋白的分泌和HeLa细胞中Dvl/2/3及LRP6的磷酸化。IWP-O1也影响胚胎发育和肿瘤形成。 

参考文献

[1] You L, et al. Development of a triazole class of highly potent Porcn inhibitors. Bioorg Med Chem Lett. 2016 Dec 15;26(24):5891-5895. 

[2] Rao DM, et al.Wnt family member 4 (WNT4) and WNT3A activate cell-autonomous Wnt signaling independent of porcupine O-acyltransferase or Wnt secretion. J Biol Chem. 2019 Dec 27;294(52):19950-19966.

[3] Torres VI, Godoy JA, Inestrosa NC. Modulating Wnt signaling at the root: Porcupine and Wnt acylation. Pharmacol Ther. 2019 Jun; 198:34-45.

冰袋运输。粉末直接保存于-20℃，有效期2年。建议分装后-20℃避光保存，避免反复冻融。