Salinomycin (Coxistac, Bio-cox, Procoxacin) sodium salt，是一种钾离子载体抗生素，抑制革兰氏阳性菌的生长，曾被用作抗球虫药，具有抗癌作用。Salinomycin通过靶向药物转运体ABC（ATP结合位点）、Wnt/β-catenin及其他CSC信号通路，在多种肿瘤中杀死癌症干细胞。

参考文献

1.Bi YL, et al. Salinomycin exhibits anti-angiogenic activity against human glioma in vitro and in vivo by suppressing the VEGF-VEGFR2-AKT/FAK signaling axis. Int J Mol Med.2017;39(5):1255-1261.

2.Rai G, et al. Evaluation of growth inhibitory response of Resveratrol and Salinomycin combinations against triple negative breast cancer cells. Biomed Pharmacother. 2017;89:1142-1151.

3.Li R, et al. Salinomycin repressed the epithelial-mesenchymal transition of epithelial ovarian cancer cells via downregulating Wnt/β-catenin pathway. Onco Targets Ther. 2017;10:1317-132.

4.Chung SS, et al. Salinomycin Abolished STAT3 and STAT1 Interactions and Reduced Telomerase Activity in Colorectal Cancer Cells. Anticancer Res. 2017 Feb;37(2):445-453.

5.Wang F, et al. Salinomycin Inhibits Proliferation and Induces Apoptosis of Human Hepatocellular Carcinoma Cells In Vitro and In Vivo. PLoS One. 2012;7(12): e50638.

6.Qu H, et al. Effect of salinomycin on metastasis and invasion of bladder cancer cell line T24. Asian Pac J Trop Med. 2015;8(7):578-82.

冰袋运输。粉末直接保存于-20℃，有效期3年。建议分装后-20℃干燥保存，避免反复冻融。