Ravoxertinib hydrochloride (GDC-0994 hydrochloride; GDC0994 hydrochloride) 是特异性的ERK抑制剂，其对ERK2有高效的抑制作用（IC₅₀=3.1 nM），对ERK1的抑制作用也很强，比ERK2的活性低1倍。Ravoxertinib hydrochloride抑制ERK磷酸化及ERK介导的信号通路的激活，有效抑制肿瘤细胞的增殖，遏制肿瘤生长。 

参考文献

[1]. Lai M. Opportunity for Pharmaceutical Intervention in Lung Cancer: Selective Inhibition of JAK1/2 to Eliminate EMT-Derived Mesenchymal Cells. 2016. 

[2]. Blake JF, et al. Discovery of (S)-1-(1-(4-Chloro-3-fluorophenyl)-2-hydroxyethyl)-4-(2-((1-methyl-1H-pyrazol-5-yl) amino) pyrimidin -4-yl) pyridin-2(1H)-one (GDC-0994), an Extracellular Signal-Regulated Kinase 1/2 (ERK1/2) Inhibitor in Early Clinical Development.J Med Chem. 2016.

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