醋酸氢化可的松 Hydrocortisone acetate 皮质类固醇|CAS 50-03-3（58523ES）

20(S)-hydroxyCholesterol（20α-Hydroxycholesterol, (3β)-Cholest-5-ene-3,20-diol, 20α-羟基胆固醇）是Hedgehog信号通路平滑癌蛋白的变构激活剂（Smo激活剂），是最有效的Hh报告基因转录诱导物。 

参考文献

[1]. Nachtergaele S, et al. Oxysterols are allosteric activators of the oncoprotein Smoothened. Nat Chem Biol. 2012 Jan 8;8(2):211-20. doi: 10.1038/nchembio.765. PMID: 22231273; PMCID: PMC3262054.

[2]. Huang Y, et al. 20(S)-hydroxycholesterol and simvastatin synergistically enhance osteogenic differentiation of marrow stromal cells and bone regeneration by initiation of Raf/MEK/ERK signaling. J Mater Sci Mater Med. 2019 Jul 19;30(8):87. doi: 10.1007/s10856-019-6284-0. PMID: 31325047.

冰袋运输。粉末直接保存于-20℃，有效期2年。建议分装后-20℃干燥保存，避免反复冻融。