GANT 61 (NSC 136476, NSC136476, GANT61)是一种GLI的选择性抑制剂，抑制hedgehog信号，具有潜在抗癌作用。GANT 61抑制GLI1的DNA结合能力，在表达GLI1的HEK293T细胞中IC₅₀为5 μM。GLI，作为致癌基因，包含GLI1和GLI2，在多种肿瘤中组成型激活。此外，GANT 61还能选择性抑制其他信号，如糖皮质激素受体基因的转录。

参考文献

1.Mazumdar T, et al. Hedgehog signaling drives cellular survival in human colon carcinoma cells. Cancer Res. 2011 Feb 1;71(3):1092-102.

2.Fu J, et al. GANT-61 inhibits pancreatic cancer stem cell growth in vitro and in NOD/SCID/IL2R gamma null mice xenograft. Cancer Lett. 2013 Mar 1;330(1):22-32.

3.Wickstrom M, et al. Targeting the hedgehog signal transduction pathway at the level of GLI inhibits neuroblastoma cell growth in vitro and in vivo. Int J Cancer. 2013 Apr 1;132(7):1516-24.

冰袋运输。粉末直接保存于-20℃，有效期2年。建议分装后-20℃干燥保存，避免反复冻融。