Jervine（蒜藜芦碱，介芬胺，11-Ketocyclopamine，白藜芦碱）一种晶体生物碱，存在于白藜芦、美洲藜芦和藜芦属其他植物的根茎中。Jervine的生物活性是通过与7个跨膜蛋白的相互作用来介导的。Jervine结合并抑制Smoothed，Smoothed是Hedgehog信号通路的一个组成部分。在Smoothed被抑制的情况下，GLI1转录无法被激活。因此，Jervine是Hedgehog信号通路的抑制剂，其IC50值为500-700 nM。

参考文献

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冰袋运输。粉末直接保存于-20℃，有效期2年。溶于DMSO。建议分装后-20℃避光保存，避免反复冻融。