Prinaberel (ERB-041, ERB041)，也称普林贝瑞，是选择性雌激素受体β (ERβ)高效激动剂，对人ERβ的IC₅₀为5.4 nM，选择性是ERα的200倍以上。Prinaberel具有抗癌作用。

参考文献

1.Malamas MS, et al. Design and synthesis of aryl diphenolic azoles as potent and selective estrogen receptor-beta ligands. J Med Chem. 2004;47(21):5021-5040.

2.Chaudhary SC, et al. Erb-041, an estrogen receptor-β agonist, inhibits skin photocarcinogenesis in SKH-1 hairless mice by downregulating the WNT signaling pathway. Cancer Prev Res (Phila). 2014;7(2):186-198.

3.Chan KKL, et al. Estrogen receptor modulators genistein, daidzein and ERB-041 inhibit cell migration, invasion, proliferation and sphere formation via modulation of FAK and PI3K/AKT signaling in ovarian cancer. Cancer Cell Int. 2018;18:65.

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