Bohemine是一种嘌呤类似物，是细胞周期依赖性的激酶抑制剂，具有良好的抗癌活性。Bohemine是CDK抑制剂，对 Cdk2/cyclin E、Cdk2/cyclin A、Cdk9/cyclin T1的IC₅₀值分别为4.6 μM，83 μM、2.7 μM。

参考文献

[1]. Franek F, et al. Diverse effects of the cyclin-dependent kinase inhibitor bohemine: Concentration- and time-dependent suppression or stimulation of hybridoma culture. Cytotechnology. 2001 Jul;36(1-3):117-23.

[2]. Raynaud FI, et al. In vitro and in vivo pharmacokinetic-pharmacodynamic relationships for the trisubstituted aminopurine cyclin-dependent kinase inhibitors olomoucine, bohemine and CYC202. Clin Cancer Res. 2005 Jul 1;11(13):4875-87.

[3]. Kim K, et al. Blockade of the MEK/ERK signalling cascade by AS703026, a novel selective MEK1/2 inhibitor, induces pleiotropic anti-myeloma activity in vitro and in vivo. Br J Haematol. 2010 May;149(4):537-49.

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