Methylnissolin（Astrapterocarpan，黄芪紫檀烷苷）是从黄芪 (Astragalus membranaceus) 中分离的出来的一种化合物，可以抑制PDGF-BB刺激诱导的ERK1/2的激活，抑制丝裂原活化蛋白(MAP)激酶的磷酸化。Methylnissolin通过抑制ERK1/2 MAP激酶级联反应途径，抑制PDGF-BB诱导的血管平滑肌细胞增殖，其IC₅₀值为10 μM。除此之外，Methylnissolin抑制PDGF-BB诱导的细胞外信号调节激酶1/2 (ERIC1/2)丝裂原活化蛋白(MAP)激酶的磷酸化。

参考文献

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[3]. Yang DH, et al. Absorptive constituents and their metabolites in drug-containing urine samples from Wuzhishan miniature pigs orally administered with Buyang Huanwu decoction. J Nat Med. 2014 Jan;68(1):11-21. 

冰袋运输。粉末直接保存于-20℃，有效期2年。建议分装后-20℃干燥保存，避免反复冻融。