Crizotinib（克里唑替尼）是一种有效的针对ALK（间变淋巴瘤激酶）、ROS1和另一个癌基因受体酪氨酸激酶MET的小分子酪氨酸激酶抑制剂(TKI)，其对c-Met和ALK的IC₅₀分别是11 nM 和 24 nM。Crizotinib（克里唑替尼）可在多种肺癌细胞系中通过抑制STAT3信号通路来诱导细胞自噬，常用于间变性淋巴瘤激酶(ALK)阳性的局部晚期或转移性非小细胞肺癌(NSCLC)患者的治疗。

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