Motesanib Diphosphate (AMG-706)是一种有效的、可口服的、ATP竞争型的多受体酪氨酸激酶抑制剂，对VEGFR1/2/3的IC50值分别为2 nM/3 nM/6 nM，对Kit (c-Kit)具有相似的抑制活性，具有潜在抗肿瘤活性。

参考文献

[1]. Polverino A, et al. AMG 706, an oral, multikinase inhibitor that selectively targets vascular endothelial growth factor, platelet-derived growth factor, and kit receptors, potently inhibits angiogenesis and induces regression in tumor xenografts. Cancer Res. 2006 Sep 1;66(17):8715-21.

[2]. Coxon A, et al. Broad antitumor activity in breast cancer xenografts by motesanib, a highly selective, oral inhibitor of vascular endothelial growth factor, platelet-derived growth factor, and Kit receptors. Clin Cancer Res, 2009, 15(1), 110-118.

冰袋运输。粉末直接保存于-20℃，有效期2年。溶于DMSO。建议分装后-20℃避光保存，避免反复冻融。