Poziotinib是一种口服有效的不可逆泛HER抑制剂;该化合物通过诱导细胞凋亡与G1期周期阻滞发挥抗肿瘤活性,目前已进入二期临床试验。
| 英文别名 (English Synonym) | Poziotinib |
| 中文名称 (Chinese Name) | |
| 靶点 (Target) | HER2 |
| 通路 (Pathway) | Protein Tyrosine Kinase |
| CAS号 (CAS NO.) | 1092364-38-9 |
| 分子式 (Formula) | C23H21Cl2FN4O3 |
| 分子量 (Molecular Weight) | 491.34 |
| 纯度 (Purity) | ≥98% |
| 溶解性 (Solubility) | 溶于DMSO |
-25~-15℃保存,有效期3年
[1] Nam HJ, Kim HP, Yoon YK, Hur HS, Song SH, Kim MS, Lee GS, Han SW, Im SA, Kim TY, Oh DY, Bang YJ. Antitumor activity of HM781-36B, an irreversible Pan-HER inhibitor, alone or in combination with cytotoxic chemotherapeutic agents in gastric cancer. Cancer Lett. 2011 Mar 28;302(2):155-65. doi: 10.1016/j.canlet.2011.01.010. PMID: 21306821.[2]Cha MY, Lee KO, Kim M, Song JY, Lee KH, Park J, Chae YJ, Kim YH, Suh KH, Lee GS, Park SB, Kim MS. Antitumor activity of HM781-36B, a highly effective pan-HER inhibitor in erlotinib-resistant NSCLC and other EGFR-dependent cancer models. Int J Cancer. 2012 May 15;130(10):2445-54. doi: 10.1002/ijc.26276. Epub 2011 Aug 24. PMID: 21732342.[3]Kang MH, Moon SU, Sung JH, Kim JW, Lee KW, Lee HS, Lee JS, Kim JH. Antitumor Activity of HM781-36B, alone or in Combination with Chemotherapeutic Agents, in Colorectal Cancer Cells. Cancer Res Treat. 2016 Jan;48(1):355-64. doi: 10.4143/crt.2014.260. Epub 2015 Mar 5. PMID: 25761479; PMCID: PMC4720083.





