BMS777607(BMS-777607)是一种新型有效的、选择性的、可口服的ATP竞争型Met激酶抑制剂，对c-Met、Axl、Ron、Tyro3的IC50值分别是3.9 nM、1.1 nM、1.8 nM、4.3 nM。BMS777607能有效抑制c-Met的自磷酸化。

参考文献

[1]. Dai Y, et al. Impact of the small molecule Met inhibitor BMS-777607 on the metastatic process in a rodent tumor model with constitutive c-Met activation. Clin Exp Metastasis. 2012 Mar;29(3):253-61.

[2]. Schroeder GM, et al. Discovery of N-(4-(2-amino-3-chloropyridin-4-yloxy)-3-fluorophenyl) -4-ethoxy-1-(4-fluorophenyl) -2-oxo-1,2-dihydropyridine-3-carboxamide, (BMS-777607), a selective and orally efficacious inhibitor of the Met kinase superfamily. J Med Chem. 2009 Mar 12;52(5):1251-4.

冰袋运输。粉末直接保存于-20℃，有效期2年。溶于DMSO。建议分装后-20℃避光保存，避免反复冻融。