Fluticasone是一种用于呼吸道研究的吸入性皮质类固醇，同时也是Smoothened（Smo）激动剂（IC₅₀为99nM），能激活Hedgehog信号通路，进而促进初生神经干细胞或前体细胞的增殖。

[1] Wang J, Lu J, Bond MC, Chen M, Ren XR, Lyerly HK, Barak LS, Chen W. Identification of select glucocorticoids as Smoothened agonists: potential utility for regenerative medicine. Proc Natl Acad Sci U S A. 2010 May 18;107(20):9323-8. doi: 10.1073/pnas.0910712107. Epub 2010 May 3. PMID: 20439738; PMCID: PMC2889058.[2]Wang Y, Ninaber DK, van Schadewijk A, Hiemstra PS. Tiotropium and Fluticasone Inhibit Rhinovirus-Induced Mucin Production via Multiple Mechanisms in Differentiated Airway Epithelial Cells. Front Cell Infect Microbiol. 2020 Jun 19;10:278. doi: 10.3389/fcimb.2020.00278. PMID: 32637364; PMCID: PMC7318795.[3]Singanayagam A, Glanville N, Bartlett N, Johnston S. Effect of fluticasone propionate on virus-induced airways inflammation and anti-viral immune responses in mice. Lancet. 2015 Feb 26;385 Suppl 1:S88. doi: 10.1016/S0140-6736(15)60403-2. PMID: 26312910.