Pirfenidone D5 (AMR69 D5, AMR69D5, PirfenidoneD5) 是 Pirfenidone的氘代物，具有广谱抗纤维化和抗炎作用，能降低神经胶质瘤细胞密度，能抑制血清刺激的DNA合成和细胞增殖的增加。

参考文献

[1]. Burghardt I, et al. Pirfenidone inhibits TGF-β expression in malignant glioma cells[J]. Biochemical and biophysical research communications, 2007, 354(2): 542-547.

[2]. Lee B S, et al. Pirfenidone: a novel pharmacological agent that inhibits leiomyoma cell proliferation and collagen production[J]. The Journal of Clinical Endocrinology & Metabolism, 1998, 83(1): 219-223.

[3]. Isabel Burghardt, et al. Pirfenidone inhibits TGF-β expression in malignant glioma cells., 354(2), 0–547.

[4] Inomata M, et al. Pirfenidone inhibits fibrocyte accumulation in the lungs in bleomycin-induced murine pulmonary fibrosis. Respir Res. 2014 Feb 8;15: 16.

[5]. Hitoshi Nakazato; Hisashi Oku; Shoji Yamane; Yuji Tsuruta; Ryuji Suzuki (2002). A novel anti-fibrotic agent pirfenidone suppresses tumor necrosis factor-α at the translational level., 446(1-3), 177–185.

冰袋运输。粉末直接保存于-20℃，有效期2年。溶于DMSO。建议分装后-20℃避光保存，避免反复冻融。