Fusaric acid是口服有效的多通路抑制剂,核心作用与应用如下:可螯合二价金属阳离子、损伤线粒体膜,激活Caspase-3/7、-8、-9并调节Bax/Bcl-2蛋白,诱导氧化应激和凋亡;同时抑制NF-κB、TGF-β1/SMADs、PI3K/AKT/mTOR纤维化通路,减少胶原沉积;还能抑制多巴胺β-羟化酶,降低脑、心脏等组织中去甲肾上腺素和肾上腺素水平,可用于心肌纤维化、心脏肥厚改善及食管癌、肝癌等相关研究。
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