GPNMB (Glycoprotein Nonmetastatic B) is a transmembrane glycoprotein encoded by the human gene GPNMB, belonging to the immunoglobulin superfamily. Below is a detailed introduction to the GPNMB protein.

GPNMB is involved in interactions between cells, promoting cell adhesion and migration, which is particularly important in embryonic development and tissue repair. As a cell surface antigen, GPNMB plays a crucial role in regulating immune responses. It can influence macrophage polarization and modulate inflammatory responses. GPNMB has been found to be highly expressed in various cancers, such as melanoma, breast cancer, and lung cancer. Research indicates that it may contribute to tumor progression by promoting the survival, proliferation, and metastasis of tumor cells.

Research on the GPNMB protein is ongoing, with the scientific community exploring its roles in various biological processes and its potential as a therapeutic target for diseases. Moreover, advancements in technology (such as single-cell RNA sequencing and high-throughput screening) provide new opportunities for a deeper understanding of GPNMB's functions and regulation.

高纯度、高活性、低内毒素、高批间一致性

SDS-PAGE

Figure 1. On SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 95%.

Bioactivity-ELISA

Figure 2. Biotinylated Human GPNMB Protein,His-Avi Tag was immobilized at 1 μg/ml (100 μL/well) on streptavidin precoated. Increasing concentrations of Anti-GPNMB hlgG2 Antibody were added.

-85 ~ -65℃保存，收到货之日起，6个月有效期。避免反复冻融，建议等分分装为一次实验使用量，分装后，-80℃冻存。