分子生物学
IVD分子诊断
细胞培养与分析
蛋白研究
重组蛋白
细胞因子
高通量测序建库
抗体
病原检测UCF系列
生物医药
工具酶
抑制剂激活剂与常用试剂
仪器
耗材
Recombinant Human CD117 Protein,His Tag
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93764ES25
25ug
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¥ 915.00
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93764ES60
100ug
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¥ 3385.00
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93764ES76
500ug
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¥ 11305.00
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93764ES80
1mg
现货
¥ 21475.00
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Stem Cell Factor Receptor (SCF R), also known as c-Kit and CD117, is a widely expressed 145 kDa receptor tyrosine kinase. It is the cellular homolog of the feline sarcoma virus protein, v-Kit. Binding of SCF R to SCF, also known as Steel Factor and Kit Ligand, promotes the survival, differentiation, and mobilization of progenitor cells in multiple lineages. Mutations or deletions of SCF R cause a wide variety of malignancies as well as pigmentation disorders and sterility. Mature human SCF R consists of a 499 amino acid (aa) extracellular domain (ECD) with five tandem immunoglobulin-like domains, a 21 aa transmembrane segment, and a 431 aa cytoplasmic domain with the split tyrosine kinase domain. Within the ECD, human SCF R shares 73% and 76% aa sequence identity with mouse and rat SCF R, respectively. Alternative splicing of human SCF R generates a potentially secreted isoform that corresponds to the first four Ig-like domains. SCF is expressed as transmembrane and soluble noncovalent homodimers. One SCF dimer binds to two molecules of SCF R, inducing receptor dimerization and activation. Transmembrane SCF induces more prolonged signaling through SCF R compared to soluble SCF. Rat SCF is active on mouse and human cells, but human SCF is only weakly active on mouse cells. A 100 kDa glycosylated ECD fragment of SCF R can be shed into the circulation by TACE/ADAM17, and this fragment inhibits the interaction of SCF with transmembrane SCF R. SCF is a primary growth and activation factor for mast cells and eosinophils. SCF R expression on mast cells enables them to infiltrate SCF-secreting tumors where they promote tumor growth and induce local immune suppression. SCF R is up‑regulated on dendritic cells by Th2- or Th17-biasing stimuli, and it is required for subsequent dendritic cell induction of Th2 and Th17 responses.

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高纯度、高活性、低内毒素、高批间一致性

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-25 ~ -15℃保存,收到货之后有效期1年。 复溶后, 无菌条件下,-85 ~ -65℃保存,3个月有效期。

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