The protein encoded by this gene forms a heterodimer with MSH2 to form MutS beta, part of the post-replicative DNA mismatch repair system. MutS beta initiates mismatch repair by binding to a mismatch and then forming a complex with MutL alpha heterodimer. This gene contains a polymorphic 9 bp tandem repeat sequence in the first exon. The repeat is present 6 times in the reference genome sequence and 3-7 repeats have been reported. Defects in this gene are a cause of susceptibility to endometrial cancer.

推荐稀释比 WB: 1/500-1/1000  IHC: 1/50-1/100

Western

Western blot analysis of MSH3 in Hela lysates using MSH3 antibody

Immunohistochemistry

Immunohistochemistry analysis of paraffin-embedded Human esophagus cancer using MSH3 antibody. High-pressure and temperature Sodium Citrate pH 6.0 was used for antigen retrieval.

-25 ~ -15℃保存，收到货之后有效期1年，避免反复冻融。