In complex with TSC2, inhibits the nutrient-mediated or growth factor-stimulated phosphorylation of S6K1 and EIF4EBP1 by negatively regulating mTORC1 signaling. Seems not to be required for TSC2 GAP activity towards RHEB. Implicated as a tumor suppressor. Involved in microtubule-mediated protein transport, but this seems to be due to unregulated mTOR signaling.

Western

Western blot analysis of Hamartin in HeLa lysates using Hamartin antibody.

-25 ~ -15℃保存，收到货之后有效期1年，避免反复冻融。