HIF-1β is also known as AhR nuclear translocator (ARNT) due to its ability to partner with the aryl hydrocarbon receptor (AhR) to form a heterodimeric transcription factor complex. Together with AhR, HIF-1β plays an important role in xenobiotics metabolism. In addition, a chromosomal translocation leading to a TEL-ARNT fusion protein is associated with acute myeloblastic leukemia. Studies also found that ARNT/HIF-1β expression levels decrease significantly in pancreatic islets from patients with type 2 diabetes, suggesting that HIF-1β plays an important role in pancreatic β-cell function.

Western

Western blot analysis of HIF1 beta in Raw264.7, 3T3 lysates using HIF1 beta antibody.

Western

Western blot analysis of HIF1 beta in Hela, CHO-K1, C6, Ramos lysates using HIF1 beta antibody.

Immunohistochemistry

Immunohistochemistry analysis of paraffin-embedded Human lung cancer using HIF1 beta antibody. High-pressure and temperature Sodium Citrate pH 6.0 was used for antigen retrieval.

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