Translation repressor protein 4E-BP1 (also known as PHAS-1) inhibits cap-dependent translation by binding to the translation initiation factor eIF4E. Hyperphosphorylation of 4E-BP1 disrupts this interaction and results in activation of cap-dependent translation. Both the PI3 kinase/Akt pathway and FRAP/mTOR kinase regulate 4E-BP1 activity.

稀释比  WB: 1/500-1/1000；IHC: 1/50-1/100

-25 ~ -15℃保存，收到货之后有效期1年，避免反复冻融。