This gene, CYP1A1, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by some polycyclic aromatic hydrocarbons (PAHs), some of which are found in cigarette smoke. The enzyme's endogenous substrate is unknown; however, it is able to metabolize some PAHs to carcinogenic intermediates. The gene has been associated with lung cancer risk. A related family member, CYP1A2, is located approximately 25 kb away from CYP1A1 on chromosome 15. Alternative splicing results in multiple transcript variants encoding distinct isoforms.

Western

Western blot analysis of Cytochrome P450 1A1 in mouse lung lysates using Cytochrome P450 1A1 antibody

Immunohistochemistry

Immunohistochemistry analysis of paraffin-embedded Human tonsil using Cytochrome P450 1A1 antibody. High-pressure and temperature Sodium Citrate pH 6.0 was used for antigen retrieval.

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