MicroRNA-141 binds to the nerve growth factor receptor associated protein 1 gene and restores the erectile function of diabetic rats through down-regulating the nerve growth factor/neurotrophin receptor p75 (NGF/p75NTR) signaling
Yan Wen, Guohui Liu, Linpei Jia, Wei Ji, Hai Li
Journal：JOURNAL OF CELLULAR BIOCHEMISTRY
IF：2.96
DOI：10.1002/jcb.28071
PMID：
Published：2018-11-13
research field：分子生物学内分泌学泌尿科学
Abstract
Erectile dysfunction (ED) is one of the major complications in diabetes mellitus (DM). We have previously reported that the nerve growth factor (NGF)/tyrosine kinase receptor (TrkA) signaling is actively involved in DM‐induced ED (DMED). Here, we investigate the effect of micro‐RNA‐141 (miR‐141) on the NGF/p75 neurotrophin receptor (p75NTR) signaling and erectile function of diabetic rats.
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