Phenazopyridine HCl是一种竞争性SARM1抑制剂和TRPM8拮抗剂,具有局部麻醉/止痛作用,可用于缓解膀胱炎及尿道炎等相关疼痛。此外,它还能促进神经分化,并用于创伤性脑损伤、周围神经病变及神经退行性疾病的研究。
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英文别名 (English Synonym) |
Phenazopyridine HCl |
|
中文名称 (Chinese Name) |
盐酸非那吡啶；菲那吡啶盐酸盐 |
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靶点 (Target) |
Sodium Channel |
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通路 (Pathway) |
Membrane Transporter/Ion Channel |
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CAS号 (CAS NO.) |
136-40-3 |
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分子式 (Formula) |
C11H11N5·HCl |
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分子量 (Molecular Weight) |
249.7 |
|
纯度 (Purity) |
≥98% |
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溶解性 (Solubility) |
溶于DMSO |
-25~-15℃保存，有效期3年
[1] Wang C, Zhang Y, Zhao D, Huo Y, Xie J, Zhang X, Luo H, Xu H, Zhang YW. Phenazopyridine promotes RPS23RG1/Rps23rg1 transcription and ameliorates Alzheimer-associated phenotypes in mice. Neuropsychopharmacology. 2022 Nov,47(12):2042-2050. doi: 10.1038/s41386-022-01373-7. Epub 2022 Jul 11. PMID: 35821069, PMCID: PMC9556769.[2]Aizawa N, Wyndaele JJ. Effects of phenazopyridine on rat bladder primary afferent activity, and comparison with lidocaine and acetaminophen. Neurourol Urodyn. 2010 Nov,29(8):1445-50. doi: 10.1002/nau.20886. PMID: 20976818.
