Procainamide hydrochloride是一种强效特异性的DNMT1抑制剂,它可通过去甲基化重新激活肿瘤抑制基因,诱导细胞空泡化并抑制增殖与迁移,它还能通过激活钾通道松弛气管平滑肌,适用于癌症与心律失常的研究。
|
英文别名 (English Synonym) |
Procainamide HCl |
|
中文名称 (Chinese Name) |
盐酸普鲁卡因胺 |
|
靶点 (Target) |
Sodium Channel |
|
通路 (Pathway) |
Membrane Transporter/Ion Channel |
|
CAS号 (CAS NO.) |
614-39-1 |
|
分子式 (Formula) |
C13H22ClN3O |
|
分子量 (Molecular Weight) |
271.79 |
|
纯度 (Purity) |
≥98% |
|
溶解性 (Solubility) |
溶于DMSO |
-25~-15℃保存，有效期3年
[1] Morissette G, Moreau E, C-Gaudreault R, Marceau F. Massive cell vacuolization induced by organic amines such as procainamide. J Pharmacol Exp Ther. 2004 Jul,310(1):395-406. doi: 10.1124/jpet.104.066084. Epub 2004 Mar 8. PMID: 15007104.[2]Segura-Pacheco B, Trejo-Becerril C, Perez-Cardenas E, Taja-Chayeb L, Mariscal I, Chavez A, Acuña C, Salazar AM, Lizano M, Dueñas-Gonzalez A. Reactivation of tumor suppressor genes by the cardiovascular drugs hydralazine and procainamide and their potential use in cancer therapy. Clin Cancer Res. 2003 May,9(5):1596-603. PMID: 12738711.
