Riluzole是一种抗惊厥药物,属于使用依赖性钠通道阻滞剂,并能抑制 GABA 摄取。
|
英文别名 (English Synonym) |
Riluzole |
|
中文名称 (Chinese Name) |
利鲁唑 |
|
靶点 (Target) |
Sodium Channel |
|
通路 (Pathway) |
Membrane Transporter/Ion Channel |
|
CAS号 (CAS NO.) |
1744-22-5 |
|
分子式 (Formula) |
C8H5F3N2OS |
|
分子量 (Molecular Weight) |
234.2 |
|
纯度 (Purity) |
≥98% |
|
溶解性 (Solubility) |
溶于DMSO |
-25~-15℃保存，有效期3年
[1] He Y, Benz A, Fu T, Wang M, Covey DF, Zorumski CF, Mennerick S. Neuroprotective agent riluzole potentiates postsynaptic GABA(A) receptor function. Neuropharmacology. 2002 Feb,42(2):199-209. doi: 10.1016/s0028-3908(01)00175-7. PMID: 11804616.[2]Thompson JM, Ji G, Neugebauer V. Small-conductance calcium-activated potassium (SK) channels in the amygdala mediate pain-inhibiting effects of clinically available riluzole in a rat model of arthritis pain. Mol Pain. 2015 Aug 28,11:51. doi: 10.1186/s12990-015-0055-9. PMID: 26311432, PMCID: PMC4551697.
