Diltiazem HCl是一种钙离子内流抑制剂(慢通道阻滞剂或钙拮抗剂)，作为苯并硫氮杂䓬衍生物，通过抑制钙离子跨膜功能发挥血管舒张作用。
| 英文别名 (English Synonym) | Diltiazem HCl |
| 中文名称 (Chinese Name) | 盐酸地尔硫卓 |
| 靶点 (Target) | Calcium Channel |
| 通路 (Pathway) | Membrane Transporter/Ion Channel |
| CAS号 (CAS NO.) | 33286-22-5 |
| 分子式 (Formula) | C22H26N2O4S·HCl |
| 分子量 (Molecular Weight) | 450.98 |
| 纯度 (Purity) | ≥98% |
| 溶解性 (Solubility) | 溶于DMSO |
-25~-15℃保存，有效期3年
[1] Kraus RL, Hering S, Grabner M, Ostler D, Striessnig J. Molecular mechanism of diltiazem interaction with L-type Ca2+ channels. J Biol Chem. 1998 Oct 16;273(42):27205-12. doi: 10.1074/jbc.273.42.27205. PMID: 9765241.[2]van Breemen C, Hwang O, Meisheri KD. The mechanism of inhibitory action of diltiazem on vascular smooth muscle contractility. J Pharmacol Exp Ther. 1981 Aug;218(2):459-63. PMID: 7252845.[3]Chiesi M, Rogg H, Eichenberger K, Gazzotti P, Carafoli E. Stereospecific action of diltiazem on the mitochondrial Na-Ca exchange system and on sarcolemmal Ca-channels. Biochem Pharmacol. 1987 Sep 1;36(17):2735-40. doi: 10.1016/0006-2952(87)90257-7. PMID: 2443142.[4]Freitas F, Estato V, Lessa MA, Tibiriçá E. Cardiac microvascular rarefaction in hyperthyroid rats is reversed by losartan, diltiazem, and propranolol. Fundam Clin Pharmacol. 2015 Feb;29(1):31-40. doi: 10.1111/fcp.12075. Epub 2014 Apr 22. PMID: 24689791.[5]Sato M, Murata S, Narita H, Tomita M, Yamashita K, Yamaguchi I. [Hypotensive effects of diltiazem hydrochloride in the normotensive, spontaneously hypertensive and renal hypertensive rats (author's transl)]. Nihon Yakurigaku Zasshi. 1979 Mar;75(2):99-106. Japanese. doi: 10.1254/fpj.75.99. PMID: 535823.
