Gabapentin hydrochloride是一种口服有效的GABA类似物,通过阻断P/Q型Ca2+通道抑制神经元Ca2+内流与神经递质释放,从而用于缓解神经性疼痛。
|
英文别名 (English Synonym) |
Gabapentin HCl |
|
中文名称 (Chinese Name) |
加巴喷丁盐酸盐 |
|
靶点 (Target) |
Calcium Channel |
|
通路 (Pathway) |
Membrane Transporter/Ion Channel |
|
CAS号 (CAS NO.) |
60142-95-2 |
|
分子式 (Formula) |
C9H18ClNO2 |
|
分子量 (Molecular Weight) |
207.7 |
|
纯度 (Purity) |
≥98% |
|
溶解性 (Solubility) |
溶于DMSO |
-25~-15℃保存，有效期3年
[1] Fink K, Meder W, Dooley DJ, Göthert M. Inhibition of neuronal Ca(2+) influx by gabapentin and subsequent reduction of neurotransmitter release from rat neocortical slices. Br J Pharmacol. 2000 Jun,130(4):900-6. doi: 10.1038/sj.bjp.0703380. PMID: 10864898, PMCID: PMC1572136.[2]Celikyurt IK, Mutlu O, Ulak G, Akar FY, Erden F. Gabapentin, A GABA analogue, enhances cognitive performance in mice. Neurosci Lett. 2011 Apr 1,492(2):124-8. doi: 10.1016/j.neulet.2011.01.072. Epub 2011 Feb 4. PMID: 21296127.
