Triamterene是一种压敏型上皮钠离子通道（ENaC）阻断剂和TGR5受体抑制剂,具有利尿作用。
|
英文别名 (English Synonym) |
Triamterene |
|
中文名称 (Chinese Name) |
氨苯蝶啶 |
|
靶点 (Target) |
Sodium Channel |
|
通路 (Pathway) |
Membrane Transporter/Ion Channel |
|
CAS号 (CAS NO.) |
396-01-0 |
|
分子式 (Formula) |
C12H11N7 |
|
分子量 (Molecular Weight) |
253.26 |
|
纯度 (Purity) |
≥98% |
|
溶解性 (Solubility) |
溶于DMSO |
-25~-15℃保存，有效期3年
[1] Park NY, Jo DS, Kim YH, Bae JE, Kim JB, Park HJ, Choi JY, Lee HJ, Chang JH, Bunch H, Jeon HB, Jung YK, Cho DH. Triamterene induces autophagic degradation of lysosome by exacerbating lysosomal integrity. Arch Pharm Res. 2021 Jun,44(6):621-631. doi: 10.1007/s12272-021-01335-5. Epub 2021 Jun 7. PMID: 34100261, PMCID: PMC8254722.[2]Shafaroodi H, Barati S, Ghasemi M, Almasirad A, Moezi L. A role for ATP-sensitive potassium channels in the anticonvulsant effects of triamterene in mice. Epilepsy Res. 2016 Mar,121:8-13. doi: 10.1016/j.eplepsyres.2016.01.003. Epub 2016 Jan 18. PMID: 26855365.
