分子生物学
IVD分子诊断
细胞培养与分析
蛋白研究
细胞因子
重组蛋白
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高通量测序建库
病原检测UCF系列
生物医药
工具酶
抑制剂激活剂与常用试剂
仪器
耗材
Bupivacaine HCl
产品详情
FAQ
产品文档
已发表文献
产品介绍

Bupivacaine HCl是一种NMDA受体抑制剂,可阻断钠通道、L-型钙通道及钾通道;该药物通过与钠通道胞内结构域结合阻断神经细胞钠离子内流,适用于慢性疼痛及心律失常的研究。

产品性质
产品特色
英文别名 (English Synonym)Bupivacaine HCl
中文名称 (Chinese Name)盐酸布比卡因
靶点 (Target)Sodium Channel
通路 (Pathway)Membrane Transporter/Ion Channel
CAS号 (CAS NO.)18010-40-7
分子式 (Formula)C18H28N2O·HCl
分子量 (Molecular Weight)324.89
纯度 (Purity)≥98%
溶解性 (Solubility)溶于DMSO


存储条件

-25~-15℃保存,有效期3年

COA
已发表文献

[1] Chu CR, Izzo NJ, Papas NE, Fu FH. In vitro exposure to 0.5% bupivacaine is cytotoxic to bovine articular chondrocytes. Arthroscopy. 2006 Jul;22(7):693-9. doi: 10.1016/j.arthro.2006.05.006. PMID: 16843803.[2]Sztark F, Malgat M, Dabadie P, Mazat JP. Comparison of the effects of bupivacaine and ropivacaine on heart cell mitochondrial bioenergetics. Anesthesiology. 1998 May;88(5):1340-9. doi: 10.1097/00000542-199805000-00026. PMID: 9605695.[3]Irwin W, Fontaine E, Agnolucci L, Penzo D, Betto R, Bortolotto S, Reggiani C, Salviati G, Bernardi P. Bupivacaine myotoxicity is mediated by mitochondria. J Biol Chem. 2002 Apr 5;277(14):12221-7. doi: 10.1074/jbc.M108938200. Epub 2002 Jan 14. PMID: 11790774.[4]Zhou W, Arrabit C, Choe S, Slesinger PA. Mechanism underlying bupivacaine inhibition of G protein-gated inwardly rectifying K+ channels. Proc Natl Acad Sci U S A. 2001 May 22;98(11):6482-7. doi: 10.1073/pnas.111447798. Epub 2001 May 15. PMID: 11353868; PMCID: PMC33494.[5]Butterworth JF 4th, Brownlow RC, Leith JP, Prielipp RC, Cole LR. Bupivacaine inhibits cyclic-3',5'-adenosine monophosphate production. A possible contributing factor to cardiovascular toxicity. Anesthesiology. 1993 Jul;79(1):88-95. doi: 10.1097/00000542-199307000-00014. Erratum in: Anesthesiology 1994 Jan;80(1):250. PMID: 8393632.[6]Zink W, Graf BM, Sinner B, Martin E, Fink RH, Kunst G. Differential effects of bupivacaine on intracellular Ca2+ regulation: potential mechanisms of its myotoxicity. Anesthesiology. 2002 Sep;97(3):710-6. doi: 10.1097/00000542-200209000-00026. PMID: 12218539.

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