Suramin sodium salt是一种多靶点抑制剂,可逆且竞争性地抑制蛋白酪氨酸磷酸酶(PTPases)、sirtuins（SirT1/2/5）、逆转录酶、SARS-CoV-2 RdRp及IP5K,并具有抗寄生虫、抗肿瘤和抗血管生成活性。
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英文别名 (English Synonym) |
Suramin hexasodium salt |
|
中文名称 (Chinese Name) |
苏拉明钠 |
|
靶点 (Target) |
P2X purinergic receptor |
|
通路 (Pathway) |
Membrane Transporter/Ion Channel |
|
CAS号 (CAS NO.) |
129-46-4 |
|
分子式 (Formula) |
C51H34N6Na6O23S6 |
|
分子量 (Molecular Weight) |
1429.15 |
|
纯度 (Purity) |
≥98% |
|
溶解性 (Solubility) |
可溶于水（必要时需加热或超声助溶）或DMSO；微溶于甲醇（浓度太大时，需要超声、加热助溶） |
-25~-15℃保存，有效期3年
[1] Jindal HK, Anderson CW, Davis RG, Vishwanatha JK. Suramin affects DNA synthesis in HeLa cells by inhibition of DNA polymerases. Cancer Res. 1990 Dec 15,50(24):7754-7. PMID: 2174730.[2]Zhang X, Shi S, Su Y, Yang X, He S, Yang X, Wu J, Zhang J, Rao F. Suramin and NF449 are IP5K inhibitors that disrupt inositol hexakisphosphate-mediated regulation of cullin-RING ligase and sensitize cancer cells to MLN4924/pevonedistat. J Biol Chem. 2020 Jul 24,295(30):10281-10292. doi: 10.1074/jbc.RA120.014375. Epub 2020 Jun 3. PMID: 32493769, PMCID: PMC7383383.
