Tolbutamide
产品介绍
Tolbutamide是一种口服有效的ATP敏感性钾通道抑制剂，通过抑制细胞增殖、刺激胰高血糖素胞吐作用及降低小鼠胎儿死亡率，可用于2型糖尿病的研究。
产品性质
产品特色
| 英文别名 (English Synonym) | Tolbutamide |
| 中文名称 (Chinese Name) | 甲苯磺丁脲 |
| 靶点 (Target) | Potassium Channel |
| 通路 (Pathway) | Membrane Transporter/Ion Channel |
| CAS号 (CAS NO.) | 64-77-7 |
| 分子式 (Formula) | C12H18N2O3S |
| 分子量 (Molecular Weight) | 270.35 |
| 纯度 (Purity) | ≥98% |
| 溶解性 (Solubility) | 溶于DMSO |
存储条件
-25~-15℃保存，有效期3年
COA
已发表文献
[1] Sánchez-Alvarez R, Paíno T, Herrero-González S, Medina JM, Tabernero A. Tolbutamide reduces glioma cell proliferation by increasing connexin43, which promotes the up-regulation of p21 and p27 and subsequent changes in retinoblastoma phosphorylation. Glia. 2006 Aug 1;54(2):125-34. doi: 10.1002/glia.20363. PMID: 16718685.
[2] Williams AJ, Beales PE, Krug J, Procaccini E, Signore A, Xu S, Gale EA, Pozzilli P. Tolbutamide reduces the incidence of diabetes mellitus, but not insulitis, in the non-obese-diabetic mouse. Diabetologia. 1993 Jun;36(6):487-92. doi: 10.1007/BF02743262. PMID: 8335169.
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