Aristolochic acid A（Aristolochic acid I; TR 1736）作为马兜铃酸类化合物的主要活性成分，广泛存在于马兜铃属及细辛属药用植物中。该化合物能够显著抑制转录因子激活蛋白1（AP-1）与核因子κB（NF-κB）的活性，并下调人源细胞中膀胱癌相关基因BLCAP的表达水平。
| 英文别名 (English Synonym) | Aristolochic acid A |
| 中文名称 (Chinese Name) | 马兜铃酸A |
| 靶点 (Target) | |
| 通路 (Pathway) | Natural Products |
| CAS号 (CAS NO.) | 313-67-7 |
| 分子式 (Formula) | C17H11NO7 |
| 分子量 (Molecular Weight) | 341.27 |
| 纯度 (Purity) | ≥98% |
| 溶解性 (Solubility) | 溶于DMSO |
-25~-15℃保存，有效期3年。
[1] Huang YT, Wu TS,et al. Aristolochic acid I interferes with the expression of BLCAP tumor suppressor gene in human cells. Toxicol Lett. 2018 Jul;291:129-137. doi: 10.1016/j.toxlet.2018.03.032. Epub 2018 Apr 12. PMID: 29655784.
[2] Liu Y, He X, et al. Aristolochic acid I induces impairment in spermatogonial stem cell in rodents. Toxicol Res (Camb). 2021 Apr 26;10(3):436-445
[3] Feng C, Xie X, et al. Tanshinone I protects mice from aristolochic acid I-induced kidney injury by induction of CYP1A. Environ Toxicol Pharmacol. 2013 Nov;36(3):850-7. doi: 10.1016/j.etap.2013.07.017. Epub 2013 Aug 6. PMID: 23981375.
