Tiotropium Bromide hydrate (BA 679BR) 作为Tiotropium bromide的一水合物形式，是一种具有支气管扩张作用的抗胆碱药物，通过拮抗毒蕈碱受体发挥药理效应。
|
英文别名 (English Synonym) |
Tiotropium Bromide hydrate |
|
中文名称 (Chinese Name) |
噻托溴铵一水合物 |
|
靶点 (Target) |
AChR |
|
通路 (Pathway) |
Neuroscience |
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CAS号 (CAS NO.) |
139404-48-1 |
|
分子式 (Formula) |
C19H22NO4S2·Br·xH2O |
|
分子量 (Molecular Weight) |
490.43 |
|
纯度 (Purity) |
≥98% |
|
溶解性 (Solubility) |
溶于DMSO |
-25~-15℃保存，有效期3年
[1] Barnes PJ, Belvisi MG, Mak JC, Haddad EB, O'Connor B. Tiotropium bromide (Ba 679 BR), a novel long-acting muscarinic antagonist for the treatment of obstructive airways disease. Life Sci. 1995;56(11-12):853-9. doi: 10.1016/0024-3205(95)00020-7. PMID: 10188785. [2] Ohta S, Oda N, Yokoe T, Tanaka A, Yamamoto Y, Watanabe Y, Minoguchi K, Ohnishi T, Hirose T, Nagase H, Ohta K, Adachi M. Effect of tiotropium bromide on airway inflammation and remodelling in a mouse model of asthma. Clin Exp Allergy. 2010 Aug;40(8):1266-75. doi: 10.1111/j.1365-2222.2010.03478.x. Epub 2010 Mar 12. PMID: 20337647.
