Gatifloxacin加替沙星是第四代喹诺酮类抗生素，对金黄色葡萄球菌MS5935拓扑异构酶IV、大肠杆菌NIHJ JC-2 DNA旋转酶和HeLa细胞拓扑异构酶II的IC₅₀值分别为13.8 μg/mL、0.109 μg/mL和265 μg/mL。

参考文献

[1] Takei M, et al. Inhibitory activities of gatifloxacin (AM-1155), a newly developed fluoroquinolone, against bacterial and mammalian type II topoisomerases. Antimicrob Agents Chemother. 1998 Oct;42(10):2678-81.

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