Tenofovir Disoproxil fumarate 富马酸替诺福韦酯 核酸逆转录酶抑制剂|CAS 202138-50-9（54598ES）

Tenofovir Disoproxil fumarate，又称富马酸替诺福韦酯，是一种核酸逆转录酶抑制剂，是一种核苷酸类抗病毒药，用于治疗HIV-1和慢性乙型肝炎。Tenofovir Disoproxil fumarate是一种无环的5'-单磷酸腺苷类似物，通过整合到DNA，抑制HIV-1逆转录酶活性，终止DNA链延伸。

参考文献

[1] Ray AS, Cihlar T, Robinson KL, et al. Mechanism of active renal tubular efflux of tenofovir. Antimicrob Agents Chemother. 2006 Oct;50(10):3297-304. doi: 10.1128/AAC.00251-06(IF:4.715).

[2] Birkus G, Hitchcock MJ, Cihlar T. Assessment of mitochondrial toxicity in human cells treated with tenofovir: comparison with other nucleoside reverse transcriptase inhibitors. Antimicrob Agents Chemother. 2002 Mar;46(3):716-23. doi: 10.1128/AAC.46.3.716-723.2002(IF:4.715).

[3] Menne S, Cote PJ, Korba BE, et al. Antiviral effect of oral administration of tenofovir disoproxil fumarate in woodchucks with chronic woodchuck hepatitis virus infection. Antimicrob Agents Chemother. 2005 Jul;49(7):2720-8. doi: 10.1128/AAC.49.7.2720-2728.2005(IF:4.715).

-25~-15℃保存，有效期3年。