PACAP 1-38 (Pituitary Adenylate Cyclase Activating Polypeptide 38),又称垂体腺苷酸环化酶激活多肽38,是含有38个氨基酸残基的内源性神经肽,是PACAP受体的激动剂,作用于PACAP I型受体,PACAP II型受体VIP1和VIP2,IC50分别为 4 nM、2 nM和1 nM,具有多种生物活性,如作为神经递质、抗氧化、抗炎等。
参考文献
[1] Gourlet P, et al. Fragments of pituitary adenylate cyclase activating polypeptide discriminate between type I and II recombinant receptors. Eur J Pharmacol. 1995 Dec 4;287(1):7-11.
[2] Arimura A, et al. Potential protective action of pituitary adenylate cyclase-activating polypeptide (PACAP38) on in vitro and in vivo models of myeloma kidney injury. Blood. 2006 Jan 15;107(2):661-8.
[3] Werling D, et al. Passage through the Ocular Barriers and Beneficial Effects in Retinal Ischemia of Topical Application of PACAP (1-38) in Rodents. Int J Mol Sci. 2017 Mar 21;18(3): 675.
干冰运输。粉末直接保存于-25~15℃,有效期2年。溶解后分装后建议-85~-65℃保存,避免反复冻融。





