NPS-2143 (NPS2143, SB-262470A)是可口服的CaSR（Ca²⁺敏感受体）选择性拮抗剂，IC₅₀为43 nM，通过靶向Ca²⁺受体引起胞浆Ca²⁺浓度增加，也可刺激甲状旁腺激素的分泌。

参考文献

[1] Nemeth EF, et al. Calcilytic compounds: potent and selective Ca2+ receptor antagonists that stimulate secretion of parathyroid hormone. J Pharmacol Exp Ther. 2001 Oct;299(1):323-31.

[2] Ohsu T, et al. Involvement of the calcium-sensing receptor in human taste perception. J Biol Chem. 2010 Jan 8;285(2):1016-22.

[3] Rybczynska A, et al. Hypertensive effect of calcilytic NPS 2143 administration in rats. J Endocrinol. 2006 Oct;191(1):189-95.

冰袋运输。粉末直接保存于-25~-15℃，有效期3年。建议分装后-25~-15℃干燥保存，避免反复冻融。