PIK-294 (PIK294)是p110δ选择性抑制剂，IC₅₀为10 nM，作用于p110α/β/γ的IC₅₀为10 μM/490 nM/160 nM。PIK-294通过其m-苯酚基团进入ATP结合位点的高亲和口袋，促进抑制活性。

参考文献

[1] Knight ZA, et al. A pharmacological map of the PI3-K family defines a role for p110alpha in insulin signaling. Cell. 2006 May 19;125(4):733-47.

[2] Martin KJ, et al. The role of phosphoinositide 3-kinases in neutrophil migration in 3D collagen gels. PLoS One. 2015 Feb 6;10(2):e0116250.

冰袋运输。粉末直接保存于-25~-15℃，有效期3年。建议分装后-25~-15℃干燥保存，避免反复冻融。