PI-1840 (PI1840)是可逆的、非共价的胰凝乳蛋白酶样(CT-L)选择性抑制剂，IC₅₀值为27 nM，诱导蛋白酶体底物p27、Bax和IκB-α的积累，抑制细胞存活和活力，并诱导细胞凋亡，具有抗肿瘤活性。

参考文献

[1] Kazi A, et, al. Discovery of PI-1840, a novel noncovalent and rapidly reversible proteasome inhibitor with anti-tumor activity. J Biol Chem. 2014 Apr 25;289(17):11906-11915.

[2] Chen Y, et, al. Non covalent proteasome inhibitor PI 1840 induces apoptosis and autophagy in osteosarcoma cells. Oncol Rep. 2019 May;41(5):2803-2817.

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