Tripterin (Celastrol),又称雷公藤红素、南蛇藤素、南蛇藤醇、苦瓜甙、苦瓜苷、苦瓜素或苦瓜皂甙,是从中药雷公藤中提取的具有多种生物活性的天然化合物,是蛋白酶体抑制剂,结合并抑制20S蛋白酶体的胰凝乳蛋白酶样活性,IC50为2.5 μM,具有抗癌和抗氧化活性。
参考文献
[1] Allison AC, et al. Celastrol, a potent antioxidant and anti-inflammatory drug, as a possible treatment for Alzheimer's disease. Prog Neuropsychopharmacol Biol Psychiatry. 2001 Oct;25(7):1341-57.
[2] Kannaiyan R, et al. Celastrol inhibits tumor cell proliferation and promotes apoptosis through the activation of c-Jun N-terminal kinase and suppression of PI3 K/Akt signaling pathways. Apoptosis. 2011 Oct;16(10):1028-41.
[3] Yang H, et al. Celastrol, a triterpene extracted from the Chinese "Thunder of God Vine," is a potent proteasome inhibitor and suppresses human prostate cancer growth in nude mice. Cancer Res. 2006 May 1;66(9):4758-65.
冰袋运输。粉末直接保存于-20℃,有效期3年。建议分装后-20℃干燥保存,避免反复冻融。