RGFP966 (E-isomer, RGFP-966)是HDAC3选择性抑制剂，IC₅₀为80 nM，并且在高达15 µM的浓度下到对其他HDAC仍无抑制作用。RGFP966可以减少小鼠淋巴和髓系恶性肿瘤的增殖和诱导分化。

参考文献

[1] Buggy JJ, et al. CRA-024781: a novel synthetic inhibitor of histone deacetylase enzymes with antitumor activity in vitro and in vivo. Mol Cancer Ther. 2006 May;5(5):1309-17.

[2] Wells CE, et al. Inhibition of histone deacetylase 3 causes replication stress in cutaneous T cell lymphoma. PLoS One. 2013 Jul 22;8(7):e68915.

冰袋运输。粉末直接保存于-20℃，有效期3年。建议分装后-20℃干燥保存，避免反复冻融。